fenben lab fenbendazol is one of the broad spectrum benzimidazole (I coined it Benz) carbamate anthelmintics, approved for use in humans and veterinary medicine roughly 50 years ago. It is a very effective dewormer for chickens, turkeys, rabbits, cats, dogs, fish, reptiles and horses, as well as most other pets. It is also effective against the tapeworm genus Taenia and whipworms in humans. It works by preventing the parasite from growing new cells, thus killing it.
Fenbendazole for humans cancer has been shown to suppress tumor growth in laboratory settings and in animals. It has also been found to interfere with the ability of cancer cells to take in glucose, which is essential for their growth and proliferation. This starving of cancer cells leads to a decrease in the size of tumors, as well as decreased numbers of new cancer cells being formed. It has been reported that this effect is most likely due to the binding of fenbendazole to microtubules, inhibiting their movement and therefore blocking cell division. In addition, fenbendazole has been found to block a signaling pathway important for cell proliferation, leading to the death of cancer cells.
Although fenbendazole has been used as an animal anthelmintic for decades, research on the drug’s effectiveness in humans is limited. However, research conducted in the lab on fenbendazole’s anthelmintic properties suggests it has potential to treat human diseases such as cancer and inflammatory bowel disease (IBD).
The active compounds in fenbendazole, oxifendazole, and metronidazole are converted in the body to their respective carbamates upon ingestion. These compounds are absorbed into the gut and converted to their pharmacologically active metabolites in the liver. The metabolites are then excreted in the urine.
It is important to note that fenbendazole has not been approved for use in the treatment of cancer by the FDA. Therefore, the FDA advises patients to work with a healthcare professional who has experience in using this drug for cancer treatment.
Having said that, the repositioning of benzimidazole carbamate antihelmintic drugs for human anticancer use has been gaining momentum recently owing to their easy availability and low cost as generics, as well as their proven safety in human applications.  For example, mebendazole (MBZ), albendazole (ABZ), and fenbendazole (FZ) have been successfully repurposed as anticancer agents due to their demonstrated effectiveness in causing apoptosis and inhibiting the growth of several types of cancer.